INFORMATION FOR SPECIALISTS


Haematococcus
Pluvialis -
source of natural
Astaxanthin

Precautions / Warnings / Contraindications:

- Use cautiously in patients using 5-alpha-reductase inhibitors.
- Use cautiously in patients with hypertension or taking hypertensive agents.
- Use cautiously in patients taking asthma medications, such as etirizine dihydrochloride and azelastine.
- Use cautiously in patients taking cytochrome P450 metabolized agents.
- Use cautiously in patients taking Helicobacter pylori agents.
- Use cautiously in patients taking menopause agents or oral contraception.
- Use cautiously in patients with parathyroid disorders.
- Use cautiously in patients with osteoporosis.
- Avoid in patients with known allergy to Astaxanthin or related carotenoids.
- Avoid in patients with hormone-sensitive conditions.
- Avoid in patients with immune disorders or using immunosuppressive therapies.
- Avoid in patients who have experienced previous visual changes while taking Astaxanthin.
- Avoid in patients with low eosinophil levels.
- Avoid in patients who are pregnant or lactating.

Pregnancy & Lactation:
 
- Not recommended due to lack of sufficient data.
- Astaxanthin may be unsafe in pregnant women, as it may affect reproductive hormones via 5-alpha-reductase inhibition
.

Drug Interactions:

5-alpha-reductase inhibitors: In vitro data suggests Astaxanthin may inhibit 5-alpha-reductase.
Antihypertensive drugs: Based on an animal study, Astaxanthin may decrease blood pressure.
Antilipemics: Preliminary in vitro and ex vivo evidence suggests Astaxanthin may inhibit LDL oxidation.
Asthma medications: Based on an in vitro study, Astaxanthin may suppress T cell activation comparable to the antihistamines etirizine dihydrochloride and azelastine.
Cytochrome P450 metabolized drugs: Based on an animal study, Astaxanthin may induce CYP 3A4 and CYP2B6 enzymes.
Helicobacter pylori medications: Based on in vitro studies, Astaxanthin may inhibit Helicobacter pylori growth.
Immunomodulators: Based on in vitro study, Astaxanthin may enhance immunoglobulin (Ig) production in response to T-dependent stimuli.
Menopause medications: Based on in vitro data that Astaxanthin may inhibit 5-alpha-reductase, dihydrotestosterone and testosterone levels may be decreased, and estradiol levels may possibly increase.
Oral contraception: Based on in vitro data that Astaxanthin may inhibit 5-alpha-reductase, dihydrotestosterone and testosterone levels may be decreased, and estradiol levels may possibly increase.
Parathyroid medications: Based on in vivo study, Astaxanthin may lower serum Calcium, which may suggest parathyroid intervention.
Vioxx ® (Rofecoxib): Based on a preliminary study, Astaxanthin may decrease low density lipoprotein (LDL) oxidation caused by the Vioxx ®.

Herbs and Suplements interactions:

5-alpha-reductase inhibitor herbs (Saw Palmetto): Based on an in vitro study, the combination of Astaxanthin and Saw Palmetto leaf extract showed a 20% greater inhibition of 5-alpha-reductase than Saw Palmetto leaf extract alone.
Antilipemics: Preliminary in vitro and ex vivo evidence suggests Astaxanthin may inhibit LDL oxidation.
Calcium: Based on in vivo study, Astaxanthin may lower serum Calcium.
Carotenoids (Beta-carotene, Lutein, Canthaxanthin, Lycopene): Concomitant use of Astaxanthin with other carotenoids (Beta-carotene, Lutein, Canthaxanthin, and Lycopene) may decrease the absorption of Astaxanthin, due to competitive absorption in the gastrointestinal tract.
Cytochrome P450 metabolized herbs/supplements: Based on an animal study, Astaxanthin may induce CYP 3A4 and CYP2B6 enzymes.
Helicobacter pylori herbs/supplements: Based on in vitro studies, Astaxanthin may possess inhibitory effects on Helicobacter pylori growth.
Hypotensives: Based on an animal study, Astaxanthin may decrease blood pressure.
Immunomodulating herbs/supplements: Based on in vitro study, Astaxanthin may enhance immunoglobulin (Ig) production in response to T-dependent stimuli.
Menopause herbs/supplements: Based on in vitro data that Astaxanthin may inhibit 5-alpha-reductase, dihydrotestosterone and testosterone levels may be decreased, and estradiol levels may possibly increase.
Parathyroid herbs/supplements: Based on in vivo study, Astaxanthin may lower serum Calcium, which may suggest parathyroid intervention.

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